master's thesis
Cervical intraepithelial neoplasia (CIN). Comparison of the patohistology report and PAPA smear cytology report.

Valentina Faletar (2016)
Sveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet
Metadata
TitleCervikalna intraepitelna neoplazija (CIN). Usporedba patohistološkog i PAPA nalaza.
AuthorValentina Faletar
Mentor(s)Milanka Mrčela (thesis advisor)
Abstract
Cilj istraživanja: Ispitati podudarnost patohistoloških i PAPA nalaza na materijalu dobivenom ciljanom biopsijom cerviksa i ekskohleacijom. Ispitati podudarnost kvalitete patohistološkog uzorka i postavljene dijagnoze. Nacrt studije: Presječno istraživanje u koje su uključene 152 pacijentice s premalignim promjenama vrata maternice. Materijali i metode: U ovo istraživanje su uključene 152 pacijentice s premalignim promjenama vrata maternice kojima je učinjen PAPA test i ciljana biopsija vrata maternice. Iz dostupne medicinske dokumentacije prikupljeni su arhivski podatci o PAPA testu i patohistološkoj dijagnozi. Podatci o dobi bolesnica i citološka dijagnoza korišteni su iz uputnice, odnosno zahtjeva za PHD pregled. Izračunata je dob ispitanica u trenutku uzimanja tkiva za analizu. Podatci o kvaliteti materijala su dobiveni na temelju mikroskopske procjene prikupljenog materijala. Rezultati: Najveći je broj ispitanica s citološkom (57,2 %) i patohistološkom (55,2 %) dijagnozom cervikalne intraepitelne neoplazije tip 3. Najveći je postotak obrađenog materijala ocijenjen kao vrlo dobar (46,1 %). U većine ispitanica (92,4 %) nije postojala razlika u dijagnozi postavljenoj na temelju PAPA testa i patohistološke analize. Nije postojalo statistički značajno odstupanje u dijagnozi postavljenoj na temelju PAPA testa i patohistološke analize u ovisnosti o kvaliteti materijala. Zaključak: Postojala je jaka pozitivna korelacija između gradusa utvrđenog citologijom (PAPA test) i patohistološkom dijagnostikom (PHD). Nije postojalo statistički značajno odstupanje između dijagnoza postavljenih na temelju PAPA testa i patohistoloških analiza u ovisnosti o kvaliteti materijala.
Keywordscervical intraepithelial neoplasia (CIN) Pap test pathohistological diagnosis (PHD) punch biopsy
Parallel title (English)Cervical intraepithelial neoplasia (CIN). Comparison of the patohistology report and PAPA smear cytology report.
Committee MembersZlatko Topolovec (committee chairperson)
Valerija Miličić (committee member)
Milanka Mrčela (committee member)
GranterSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet
PlaceOsijek
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Study programme typeuniversity
Study levelintegrated undergraduate and graduate
Study programmeUniversity Graduate Studies;specialization in: medicine
Academic title abbreviationdr. med.
Genremaster's thesis
Language Croatian
Defense date2016-06-13
Parallel abstract (English)
Cervical intraepithelial neoplasia (CIN). Comparison of histological and Pap results. Objectives: The aim of this study is to examine the compatibility of pathohistological and Pap findings on material obtained by biopsy of the cervix and excohleation and examine the compatibility of quality histological pattern and diagnosis. Study design: The study is structured as a cross-sectional study of 152 subjects with premalignant lesions. Material and methodes: The study involved 152 patients with premalignant lesions in the cervix which has made a Pap test and targeted biopsy of the cervix. From the available medical records were collected archival data on Pap test and histological diagnosis. Information on age and advisable clinical diagnoses was obtained from referrals for pathohistological examination of tissue. The age of the subjects was determined at the time when tissue samples were taken for analysis. Data on the quality of materials are obtained on the basis of microscopic evaluation of the collected material. Results: The largest number of patients has cytological (57,2 %) and pathohistological (55,2 %) diagnosis of cervical intraepithelial neoplasia type 3 (CIN 3). The largest percentage of the treated material was assessed as very good (46,1 %). The majority of respondents (92,4 %) has no difference in the diagnosis set on the basis of the Pap test and pathohistological analysis. There was no statistically significant difference in the diagnosis set on the basis of the Pap test and pathohistological analysis depending on the quality of materials. Conclusion: There was a strong positive correlation between grade established on cytology (Pap test) and pathohistological diagnosis (PHD). There was no statistically significant difference in the diagnosis set on the basis of the Pap test and pathohistological analysis depending on the quality of materials.
Parallel keywords (Croatian)cervikalna intraepitelna neoplazija (CIN) ciljana biopsija cerviksa PAPA nalaz patohistološka dijagnoza (PHD)
Resource typetext
Access conditionOpen access
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:152:382541
CommitterBisera Kopf