The World Trade Organization, which follows the effects of globalization on a global scale, is focused on greater integration of countries, which is mostly related to foreign trade. Its operation is explained throughout history through a series of agreements that built its goals and on which its operation is based. Thus, through the historical operation of the General Agreement on Tariffs and Trade in order to facilitate liberal world trade, several rounds of multilateral trade negotiations have been conducted. Although there are clearly defined goals and tasks of the World Trade Organization, as well as the principles on which its work is based, it still faces a number of problems, most notably the dissatisfaction of member countries, most notably countries that are underdeveloped and not can track its limitations and requirements. Great importance is attached to the membership of the Republic of Croatia, with which membership in the European Union is closely connected. This memberships offers Croatia many opportunities that it can use and improve the economic situation. An indispensable role is played by sustainable development, where the analysis of economic indicators shows the state of Croatia and real comparisons with the goals and objectives of the World Trade Organization. The data survey refers to indicators of merchandise exports and imports by activities that are more prevalent in the Republic of Croatia, and data on GDP per capita and the ratio of employment and unemployment. The presented data try to explain the broader picture of the impact of the World Trade Organization on the economy of the Republic of Croatia, with the current role played by the pandemic caused by the Covid-19 virus, which still has a major impact on the Croatian economy and the world economy. The main conclusion of this paper refers to the lack of activities of the World Trade Organization in the context of sustainable development of the Republic of Croatia.