Low Zn concentrations in soils result with low concentrations of this element in human and animal nutrition. Since zinc is an essential element, his deficit has an adversely affects at the organism. On the other side, cadmium is a toxic element without any essential and useful effect, and because of that is better that be as little as possible in consumed foodstuffs. Agronomic biofortification results with increasing Zn concentrations in edible parts of plants, and increasing intake of this element into the human organism. The aim of this experiment was been to determine the influence foliar application of zinc on the concentration of zinc and cadmium in plant parts (especially grain) some soybean types. Biofortification experiment was carried out in 2017 on 6 soya cultivars (Korana, Sanda, Lucija, Tom, Sun, Ika) with different lenght of vegecation (00-I). The foliar application of zinc, like zinc sulphate (5.489 kg ha1ZnSeO4 × H2O), was applied in flowering phenophase of soybean. Biofortification of soya was a statistically significant effected on the amount of zinc in pods, stems and grain (increase 106%, 48.5% and 25%) and his taken out with grain yield (34.75%). The treatment didn't statistically significantly affected on the amount of cadmium in stems,pods and soybean grain, and his taken out with grain yield, but there was a decrease; 23% in stems, 31% in pods and 22.64% in grain. Cultivars significantly affected on yield, accumulation of Cd in parts of plant, and his removal with soy bean. The influence of cultivars on zinc concentration and his taken out with yield wasn't been statistically significantly. The results suggest that foliar zinc application increases his concentration in grain, pods and stems of soya. Soya varieties are not significantly different in accumulation and taking out of the applied zinc, but are different in accumulation and taking out of cadmium with yield. The results of a significant increase Zn concentration in soybean grain by agronomic biofortification and at the same time significant differences between soya varieties in yield and concentrations of cadmium in the grain indicate that with careful selection of varieties and biofortification we can produce soya grain with high zinc,and at the same time low cadmium concentration, and sufficiently high yields .