master's thesis
Characteristics of the skull base meningothelial tumors

Irina Bagić (2016)
Metadata
TitleZnačajke meningotelijalnih tumora lubanjske osnovice
AuthorIrina Bagić
Mentor(s)Bruno Splavski (thesis advisor)
Abstract
Cilj istraživanja: Ispitati postoji li povezanost između bolesnikove dobi i spola, kao i stanja svijesti, lokalizacije tumora, opsežnosti kirurškog uklanjanja, patohistološkog stupnja tumora, poslijeoperacijskih komplikacija i konačnog ishoda liječenja meningeoma lubanjske osnovice. Nacrt studije: Presječna studija. Ispitanici i metode: U istraživanje su uključeni svi bolesnici s dijagnosticiranim meningeomom lubanjske osnovice koji su liječeni u Klinici za neurokirurgiju KBC-a Osijek u razdoblju od 2000. do 2015. godine. Podatci ispitanika preuzeti su iz medicinske dokumentacije pohranjene u arhivu Klinike za neurokirurgiju KBC-a Osijek. Konačni ishod liječenja određen je Karnofskyjevim indeksom (KPI) pri otpustu iz bolnice te Glasgowskom ljestvicom ishoda (GOS) unutar jedne godine od otpusta iz bolnice. Rezultati: Meningeom lubanjske osnovice dijagnosticiran je u 109 bolesnika. Medijan dobi bio je 63,0 godine, a značajno je više bilo ispitanika ženskoga spola (72,5 %). Pokazatelji ishoda, GOS i KPI, statistički su značajno povezani s dobi (p = 0,043; p = 0,047), stanjem svijesti bolesnika (p = 0,010; p < 0,001) i opsežnosti kirurškog uklanjanja tumora (p = 0,032; p < 0,001). Nije bilo statistički značajne povezanosti spola, lokalizacije tumora, patohistološkog stupnja tumora i poslijeoperacijskih komplikacija s ishodom liječenja. Zaključak: Bolesnici starije životne dobi imaju lošiji ishod liječenja. Spol bolesnika ne utječe na ishod liječenja. Bolesnici s očuvanim ili manje narušenim stanjem svijesti imaju bolji ishod liječenja. Lokalizacija tumora bitno ne utječe na ishod liječenja. Bolesnici kojima je tumor uklonjen u cijelosti imaju bolji ishod liječenja. Patohistološki stupanj i poslijeoperacijske komplikacije ne utječu na ishod liječenja.
Keywordsmeningioma skull base treatment outcome
Parallel title (English)Characteristics of the skull base meningothelial tumors
Committee MembersJozo Kristek (committee chairperson)
Branko Radanović (committee member)
Bruno Splavski (committee member)
GranterSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet
PlaceOsijek
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Study programme typeuniversity
Study levelintegrated undergraduate and graduate
Study programmeUniversity Graduate Studies
Academic title abbreviationdr. med.
Genremaster's thesis
Language Croatian
Defense date2016-07-20
Parallel abstract (English)
Objectives: To examine whether is a correlation between patient age and gender, level of consciousness, tumor localization, extent of surgical resection, pathohistological grade of tumor, postoperative complications and outcome of skull base meningioma management. Study Design: Cross-sectional study. Patients and methods: The study included all patients with skull base meningioma treated at the Department of Neurosurgery, Osijek Clinical Hospital Centre from 2000 to 2015. The partients' data were obtained from medical records contained in the archive of the Department of Neurosurgery, Osijek Clinical Hospital Centre. The outcome measure was obtained by Karnofsky Performance Index (KPI) at discharge and Glasgow Outcome Scale (GOS) at one year follow-up. Results: Skull base meningioma was diagnosed in 109 patients. Median age was 63 years, with a significantly female predominance (72.5 %). Outcome measure variables, GOS and KPI, showed statistically significant correlation with patients' age (p = 0.043; p = 0.047), level of consciousness at admission (p = 0.010; p < 0.001) and extent of surgical resection (p = 0.032; p < 0.001). There was no statistically significant correlation between the outcome and certain variables such as gender, tumor localization and pathohistological grade, as well as postoperative complications. Conclusion: The outcome was correlated to patients’ age, but not their gender. Older patients experienced a poorer outcome. The level of consciousness at admission was a strong outcome predictor too. Patients whose consciousness was unaffected had a better chance of favorable outcome. The outcome was not affected by tumor localization, pathohistological grade and/or postoperative complications. However, it was much better in patients whose tumor was completely resected.
Parallel keywords (Croatian)ishod liječenja lubanjska osnovica meningeom.
Resource typetext
Access conditionOpen access
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:152:972134
CommitterBisera Kopf