undergraduate thesis
The value of serum prolactin measurement in persons old 50 years and over

Donna Vadlja (2015)
Sveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet
Metadata
TitleVrijednost mjerenja serumskog prolaktina u osoba starih 50 i više godina
AuthorDonna Vadlja
Mentor(s)Ljiljana Trtica Majnarić (thesis advisor)
Abstract
CILJ Utvrditi utječu li starija dob i prisutnost KV čimbenika rizika na varijabilnost serumske koncentracije prolaktina. NACRT STUDIJE Retrospektivna i presječna case-control studija. ISPITANICI I METODE: Uključeno je 93 pacijenta (35 muškaraca i 58 žena)u dobi od 50 do 88 godina (medijan 67) s prisutnim KV čimbenicima rizika, uzeti iz jedne ordinacije opće medicine. Za potrebe istraživanja, dijelom su korišteni podatci iz njihovih e-kartona, a neke biokemijske pretrage, uključujući i pretragu na prolaktin, dodatno su napravljene. Rađena je analiza razlika među skupinama te ispitivanje povezanosti s mulivarijatnim regresijkim modelom. REZULTATI Od 11 ispitivanih parametara, parametar CRP(p=0,17) i KEK(p= 0,001) pokazali su značajnu povezanost sa serumskom koncentracijom prolaktina. ZAKLJUČAK Čimbenici KV rizika koji bi u osoba starih od 50 i više godina mogli imati utjecaja na koncentracije prolaktina su upala niskog stupnja, smanjena kognitivna i bubrežna funkcija te promjene antropometrijskih mjera, u muškaraca više u obliku abdominalne pretilost, a u žena u obliku smanjene tjelesne mase. Svi ti čimbenici mogli bi biti i više ili manje povezani jer su povezani i sa starijom dobi. Moguće je da upala niskog stupnja i smanjena bubrežna funkcija imaju utjecaja na serumsku koncentraciju PRL-a i neovisno o starijoj dobi.
Keywordscardiovascular risk factors prolactin seniority
Parallel title (English)The value of serum prolactin measurement in persons old 50 years and over
Committee MembersJerko Barbić (committee member)
Kristina Selthofer Relatić (committee member)
Ljiljana Trtica Majnarić (committee member)
GranterSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet
PlaceOsijek
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Study programme typeuniversity
Study levelundergraduate
Study programmeUniversity undergraduate study; specializations in: medical laboratory diagnostics
Academic title abbreviationuniv. bacc. med. lab. diag.
Genreundergraduate thesis
Language Croatian
Defense date2015-09-15
Parallel abstract (English)
OBJECTIVES The aim of this study was to determine whether seniority and the presence of CV risk factors affect the variability of prolactin serum concentration. STUDY DESIGN Retrospective and cross-sectional case-control study PARTICIPANTS AND METHODS This research included 93 patients (35 male and 58 female) between 50 and 88 years of age (median 67), all with present CV risk factors. The samples were taken from the general practitioner’s dispensary. For the purposes of this research, some of the data were taken from the online database, and other tests were done additionally, such as biochemical examination, as well as the prolactin test. Variance analysis was done in different groups, as well as the correlation via multivariate analysis (MANOVA) RESULTS There were eleven parameters tested in this research. Significant results for prolactin serum concentration were found in CRP (p = 0.17) and KEK (p = 0.001) CONCLUSION CV risk factors in people older than 50 years of age that could affect the prolactin concentration are: minor inflammations, low cognitive and kidney function, anthropometric changes such as abdominal obesity in men and weight loss in female patients. All of the factors could be interconnected because they are connected with seniority. It is possible that minor inflammations and low kidney function affect PRL serum concentration independently of seniority.
Parallel keywords (Croatian)kardiovaskularni čimbenici rizika prolaktin starija dob
Resource typetext
Access conditionOpen access
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:152:138698
CommitterBisera Kopf