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master's thesis
Usporedba simptoma i kliničkih znakova laringofaringealnog refluksa s koncentracijom pepsina u slini
Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2019. urn:nbn:hr:152:195478
Rezo, Matej
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Rezo, M. (2019). Usporedba simptoma i kliničkih znakova laringofaringealnog refluksa s koncentracijom pepsina u slini (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:195478

Rezo, Matej. "Usporedba simptoma i kliničkih znakova laringofaringealnog refluksa s koncentracijom pepsina u slini." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2019. https://urn.nsk.hr/urn:nbn:hr:152:195478

Rezo, Matej. "Usporedba simptoma i kliničkih znakova laringofaringealnog refluksa s koncentracijom pepsina u slini." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2019. https://urn.nsk.hr/urn:nbn:hr:152:195478

Rezo, M. (2019). 'Usporedba simptoma i kliničkih znakova laringofaringealnog refluksa s koncentracijom pepsina u slini', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 20 April 2024, https://urn.nsk.hr/urn:nbn:hr:152:195478

Rezo M. Usporedba simptoma i kliničkih znakova laringofaringealnog refluksa s koncentracijom pepsina u slini [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2019 [cited 2024 April 20] Available at: https://urn.nsk.hr/urn:nbn:hr:152:195478

M. Rezo, "Usporedba simptoma i kliničkih znakova laringofaringealnog refluksa s koncentracijom pepsina u slini", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:152:195478

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TitleUsporedba simptoma i kliničkih znakova laringofaringealnog refluksa s koncentracijom pepsina u slini
Title (english)Comparative study of symptoms and clinical signs of laryngopharyngeal reflux with salivary pepsin concentration
AuthorMatej Rezo
MentorAndrijana Včeva (mentor)
Committee memberHrvoje Mihalj (predsjednik povjerenstva)
Committee memberŽeljko Zubčić (član povjerenstva)
Committee memberAndrijana Včeva (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2019-07-02, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Otorhinolaryngology
Abstract
Cilj: Ispitati simptome i znakove laringofaringealnog refluksa u ispitivanoj skupini prije i nakon terapije te usporediti koncentraciju pepsina u slini s navedenim. Nacrt studije: Provedeno je prospektivno longitudinalno kohortno istraživanje. Ispitanici i metode: U istraživanje je uključeno 50 ispitanika, podijeljenih u dvije skupine. Prvu skupinu činili su ispitanici sa laringofaringealnim refluksom, njih 25. Drugu skupinu činili su zdravi ispitanici bez simptoma i znakova laringofaringealnog refluksa, njih 25. Simptomi i znakovi prije i nakon terapije su prikupljeni pomoću RSI i RFS upitnika. Pepsin u slini je izmjeren pomoću Peptesta prije i nakon terapije. Rezultati: Prema spolu, 29 (58 %) je žena i 21 (42 %) je muškaraca. Od simptoma najizraženiji su promuklost, postnazalno slijevanje i osjećaj ''knedle u grlu''. Medijan RSI rezultata nakon tromjesečne terapije snižen je s 20 na 8. Iz prve skupine 7 ispitanika je imalo mjerljivu razinu pepsina u slini, a niti jedan nakon provedene terapije. U kontrolnoj skupini nijednom ispitaniku nije detektiran pepsin u slini. Zaključak: Uočeno je značajno poboljšanje u kliničkim nalazima (subglotički edem, hipertrofija stražnje komisure, edem glasnica, gusti endolaringealnog sekret). Nije uočena povezanost pepsina sa simptomima LPR-a ali postoji značajna pozitivna povezanost između pepsina i kliničkog nalaza eritema / hiperemije.
Abstract (english)
Objectives: To examine symptoms and signs of laryngopharyngeal reflux in examined group before and after treatment and compare salivary pepsin concentration with symptoms and signs of LPR. Study design: Prospective longitudinal cohort study was carried out. Participants and methods: 50 examinee's were included in this research divided into two groups. First group was consisted of 25 patients with laryngopharyngeal reflux. Second group consisted of healthy participants, also 25 of them, without symptoms and signs of laryngopharyngeal reflux. Symptoms and signs were gathered before and after treatment with RSI and RFS questionnaire. Salivary pepsin was measured with Peptest before and after treatment. Results: According to sex, 29 were women and 21 were men. The most common symptoms were hoarseness, postnasal drip and ''lump in throat''. The mean value of RSI score after three-month treatment was reduced from 20 to 8. Seven participants had salivary pepsin before treatment but none of them after treatment. None of the participants from control group had salivary pepsin. Conclusion: There is significant improvement in clinical signs (subglottic edema, posterior commisure hypertrophy, vocal fold edema and thick endolaryngeal mucus. No connection is detected between salivary pepsin and symptoms but there is significant positive connection between pepsin and clinical sign erythema / hyperemia.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:195478
Study programmeTitle: University Graduate Studies
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
RepositoryRepository of the Faculty of Medicine Osijek
Created on2019-07-25 09:37:11