undergraduate thesis
Effects of Anasthetics on Transmembrane Ion Channels

Ivana Rubić (2015)
Metadata
TitleDjelovanje anestetika na transmembranske ionske kanale
AuthorIvana Rubić
Mentor(s)Elizabeta Has Schon (thesis advisor)
Abstract
Cilj ovog rada je upoznati se sa temeljima anestezije, te mehanizmima djelovanja lokalne i opće anestezije na ionske kanale. U literaturnom pregledu opisana je povijest anestezije, razlike između lokalne i opće anestezije, te su ukratko objašnjeni osnovni pojmovi iz biokemije stanice, kao što su građa stanice, membrane te su opisane 3 vrste ionskih kanala, koji su glavna meta anestezijskog djelovanja. Opisano je molekularno djelovanje anestetika na ionske kanale, te na koje dijelove proteina djeluje anestezija. Pokazano je kako i lokalna i opća anestezija imaju različite mehanizme djelovanja, te također kako i anestetici iste vrste mogu imati različit mehanizam. U ovome radu se može vidjeti kako mehanizam djelovanja anestetika još nije u potpunosti razrađen, te da se mora još istraživati građa ionskih kanala i ostalih meta anestetika, kako bi se u potpunosti razjasnio način djelovanja anestezije.
Parallel title (English)Effects of Anasthetics on Transmembrane Ion Channels
GranterSveučilište Josipa Jurja Strossmayera u Osijeku
Odjel za kemiju
Lower level organizational unitsZavod za analitičku, organsku i primijenjenu kemiju
PlaceOsijek
StateCroatia
Scientific field, discipline, subdisciplineNATURAL SCIENCES
Chemistry
Study programme typeuniversity
Study levelundergraduate
Study programmeChemistry
Academic title abbreviationuniv. bacc. chem.
Genreundergraduate thesis
Language Croatian
Defense date2015-09-21
Parallel abstract (English)
The goal of this thesis is to learn more about the foundations of anesthesia, and the mechanisms of action of local and general anesthesia on ion channels. History of anesthesia, the differences between local and general anesthesia were described, also key terms in cell biochemistry, like the cell structure, cell membranes, and 3 different kinds of ion channels, which are the main targets of anesthetic action, were introduced. Molecular action of anesthetics on ion channels was also described, as well as the protein parts susceptible to the action of anesthesia. Difference between the actions of local and general anesthesia were also discussed. Furthermore, it was shown how anesthetics of same class can have different mechanisms of action. This thesis also states that mechanisms of anesthetics are yet not fully understood and that the further research on structure of ion channels and other targets of anesthetics has to be carried out in order to fully elucidate mechanisms of actions of anesthetics.
Parallel keywords (Croatian)anestezija lokalna anestezija opća anestezija anestetici transmembranski ionski kanali
Resource typetext
Access conditionOpen access
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:182:449534
CommitterSanda Hasenay