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undergraduate thesis
Određivanje pKa vrijednosti morina
Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2022. urn:nbn:hr:182:795094
Cepanec, Matija
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

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Cepanec, M. (2022). Određivanje pKa vrijednosti morina (Undergraduate thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:795094

Cepanec, Matija. "Određivanje pKa vrijednosti morina." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2022. https://urn.nsk.hr/urn:nbn:hr:182:795094

Cepanec, Matija. "Određivanje pKa vrijednosti morina." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2022. https://urn.nsk.hr/urn:nbn:hr:182:795094

Cepanec, M. (2022). 'Određivanje pKa vrijednosti morina', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 01 April 2023, https://urn.nsk.hr/urn:nbn:hr:182:795094

Cepanec M. Određivanje pKa vrijednosti morina [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2022 [cited 2023 April 01] Available at: https://urn.nsk.hr/urn:nbn:hr:182:795094

M. Cepanec, "Određivanje pKa vrijednosti morina", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:182:795094

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Metadata
TitleOdređivanje pKa vrijednosti morina
Title (english)Prediction of pKa values of morin
AuthorMatija Cepanec
MentorAna Amić (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2022-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Applied Chemistry
Abstract
Morin (3,5,7,2',4'-pentahidroksiflavon, C15H10O7) je bioflavonoid koji se može naći u brojim biljkama i biljnim prerađevinama. Smatra se fitokemikalijom te se ubraja u skupinu flavonola. Utvrđeno je da ima širok raspon farmakoloških djelovanja, uključujući protuupalno i antidijabetičko djelovanje, a njegova antikancerogena i antioksidacijska svojstva su predmet daljnjih istraživanja. Konstanta kisele disocijacije, pKa (također poznata kao konstanta kiselosti ili konstanta kisele ionizacije) je kvantitativna mjera jačine kiseline u otopini. Vrijednost pKa ovisi o strukturi spoja, a može se odrediti eksperimentalno i predvidjeti računalno. Međutim, pKa za brojne spojeve nije eksperimentalno određena zbog kompleksnosti njihove strukture, pa računalni programi mogu imati veliki značaj u predviđanju vrijednosti ovog parametra. U ovom radu primjenom ACD/pKa predviđene su pKa vrijednosti za morin. Korištena su dva algoritma inkorporirana u Perceptu. Dobiveni rezultati ukazuju na redoslijed disocijacije funkcijskih skupina morina te samu pH pri kojoj se disocijacija odvija.
Abstract (english)
Morin (3,5,7,2',4'-pentahydroxyflavone, C15H10O7) is a bioflavonoid and can be found in many plants and plant products. It is a phytochemical and belongs to the group of flavonols. It shows a wide range of pharmacological effects, including anti-inflammatory and antidiabetic effect, and its anticancer and antioxidant properties are still being researched. The acid dissociation constant, pKa (also known as the acidity constant or acid ionization constant) is a quantitative measure of the strength of an acid in a solution. The pKa value depends on the structure of the compound and can be determined experimentally and computationally. For many compounds, pKa has not been determined experimentally due to the complexity of their structure, so computer programs can be of great importance in predicting the value of this parameter. In this thesis, ACD/pKa was used to predict pKa values of morin. Two algorithms implemented in Percepta were used. Obtained results indicate order of dissociation of functional groups of morin and pH at which the dissociation occurs.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:795094
Study programmeTitle: Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
RepositoryRepository of the Department of Chemistry, Osijek
Created on2022-11-02 12:36:10