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undergraduate thesis
Potenciometrijska karakterizacija nanosuspenzije indometacina
Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2019. urn:nbn:hr:182:265579
Perković, Zvonimir
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

Cite this document

Perković, Z. (2019). Potenciometrijska karakterizacija nanosuspenzije indometacina (Undergraduate thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:265579

Perković, Zvonimir. "Potenciometrijska karakterizacija nanosuspenzije indometacina." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:182:265579

Perković, Zvonimir. "Potenciometrijska karakterizacija nanosuspenzije indometacina." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:182:265579

Perković, Z. (2019). 'Potenciometrijska karakterizacija nanosuspenzije indometacina', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 22 March 2023, https://urn.nsk.hr/urn:nbn:hr:182:265579

Perković Z. Potenciometrijska karakterizacija nanosuspenzije indometacina [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2019 [cited 2023 March 22] Available at: https://urn.nsk.hr/urn:nbn:hr:182:265579

Z. Perković, "Potenciometrijska karakterizacija nanosuspenzije indometacina", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:182:265579

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Metadata
TitlePotenciometrijska karakterizacija nanosuspenzije indometacina
Title (english)Potentiometric characterization of indomethacin nanosuspension
AuthorZvonimir Perković
MentorAleksandar Sečenji (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2019-09-16, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
Indometacin je lijek koji posjeduje protuupalna, analgetska i antipiretska svojstva. Spada u skupinu nesteroidnih protuupalnih analgetika (NSAID). Farmakološki učinak indometacina je neselektivna inhibicija enzima ciklooksigenaze. Glavni tehnološki problem kod indometacina, kao i kod svih lijekova koji spadaju u BCS-II skupinu je slaba topljivost u vodi. Kako bi se poboljšala topljivost lijekova u vodi razvijene su mnoge farmaceutsko-tehnološke strategije izrade prikladnih ljekovitih oblika (kruta disperzija, emulzija, mikrokapsuliranje, itd.). Jedna od tih strategija je priprema nanokristala te izrada nanosuspenzija. U ovom radu provedena je priprema i pokušaj karakterizacije nanosuspenzije indometacina. Metode kojima se izvršila karakterizacija su: DLS, TEM i potenciometrijska titracija nanosuspenzije, s naglaskom na zadnju metodu. Prvi rezultati pokazali su očitu razliku između titracijskih krivulja, ali izračun površinskog suviška protona se nije mogao napraviti zbog neodvoljne koncetracije krute tvari i upitnog stanja pH elektrode koja je korištena pri potenciometrijskim titracijama.
Abstract (english)
Indomethacin is a drug with anti-inflamatory, analgetic and anti-pyretic properties. Indomethacin is classified as non-steroidal anti-inflamatory drug (NSAID). Pharmacological effect of indomethacin is non-selective inhibition of cyclooxygenase enzyme. Main technological problem with indomethacin, as well as with all drugs from BCS-II Class is poor solubility in water. Many pharmaceutically-technological strategies have been developed in order to improve properties of drug solubility in water (solid dispersions, emulsions, microcapsules). In this paper, the preparation and attempt to characterize indomethacine nanosuspension was performed. Methods by which the characterization was performed were: DLS, TEM and potentiometric titration of nanosuspension, with an emphasis on the latter. The first results showed obvious difference between titration curves, but calculation of surface proton excess could not be made due to insufficient concentration of the solid and questionable state of pH electrode that was used in the potentiometric titrations.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:265579
Study programmeTitle: Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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RepositoryRepository of the Department of Chemistry, Osijek
Created on2019-12-02 10:02:59