undergraduate thesis
Stereoselektivna redukcija karbonilnih spojeva pomoću enzimskih sustava iz biljnog materijala

Andrea Jurić (2013)
Sveučilište Josipa Jurja Strossmayera u Osijeku
Odjel za kemiju
Metadata
TitleStereoselektivna redukcija karbonilnih spojeva pomoću enzimskih sustava iz biljnog materijala
AuthorAndrea Jurić
Mentor(s)Nela Malatesti (thesis advisor)
Abstract
Kiralni alkoholi su važne građevne jedinice za sintezu farmaceutskih pripravaka, pesticida, feromona, aroma, mirisa i materijala poput tekućih kristala. U ovome je radu opisana redukcija jednostavnih ketona, aromatskih ketona s halogenom i ß-ketoestera u kiralne alkohole korištenjem enzima iz biljnih materijala. Acetofenon je reduciran u 1 - feniletanol korištenjem različitih biljnih kultura. Kao biokatalizatori korišteni su mrkva (Daucus carota), komorač (Foeniculum vulgare) i tikvice (Cucurbita pepo). Uz pomoć kulture Daucus carota dobiven je čisti (S)-feniletanol uz enantiomerni višak od 100 %. Z. H. Yang i suradnici su proveli redukciju 4'-kloracetofenona u (R)- ili (S)-1-(4- klorfenil)etanol i etil-4-kloracetoacetata u etil-(S)-(-)-4-klor-3-hidroksibutanoat korištenjem različitih biljnih kultura. Najbolji rezultati dobiveni su korištenjem kulture Daucus carota.
Keywordschiral alcohols acetophenone (S)-phenylethanol Daucus carota biocatalysts stereoselective reduction plant cell culture
GranterSveučilište Josipa Jurja Strossmayera u Osijeku
Odjel za kemiju
PlaceOsijek
StateCroatia
Scientific field, discipline, subdisciplineNATURAL SCIENCES
Chemistry
Study programme typeuniversity
Study levelundergraduate
Study programmeChemistry
Academic title abbreviationuniv. bacc. chem.
Genreundergraduate thesis
Language Croatian
Defense date2013
Parallel abstract (English)
Chiral alcohols are important building blocks for the synthesis of pharmaceuticals, pesticides, pheromones, flavors, fragrances and advanced materials such as liquid crystals. This work describes reduction of simple ketones, halogen-containing aromatic ketones and ß-ketoesters to chiral alcohols by enzymes from plant systems. Acetophenone is reduced to 1-phenylethanol by various plant tissues. As biocatalysts were used carrot (Daucus carota), fennel (Foeniculum vulgare) and marrow (Cucurbita pepo). Reduction of acetophenone by cultures Daucus carota afforded pure (S)-phenylethanol with 100% enantiomeric excess. Z. H. Yang and co-workers performed reduction of 4'- chloroacetophenone to (R)- or (S)-1-(4-chloro-phenyl)ethanol and ethyl-4- chloroacetoacetate to ethyl-(S)-(-)-4-chloro-3-hidroxybutanoate by various plant tissues. The best results were obtained using cultures Daucus carota.
Parallel keywords (Croatian)kiralni alkoholi acetofenon (S)-feniletanol Daucus carota biokatalizatori stereoselektivna redukcija kulture biljnih stanica
Resource typetext
Access conditionOpen access
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:182:904862
CommitterSanda Hasenay