undergraduate thesis
The chemistry of vitamin B6 and synthesis of novel analogues of vitamin B6

Ivana Živković (2016)
Metadata
TitleKemija vitamina B6 i sinteza novih analoga vitamina B6
AuthorIvana Živković
Mentor(s)Dean Marković (thesis advisor)
Dajana Gašo-Sokač (thesis advisor)
Abstract
Vitamin B6 je generički naziv za skupinu od šest spojeva: piridoksin, piridoksal piridoksamin i njihove 5'-fosfate odnosno 3-hidroksi-2-metil-5-hidroksimetil piridinske derivate. Prva totalna sinteza vitamina B6 je provedena kondenzacijom 1-etoksipentan-2,4-diona i cijanacetamida. Svim živim bićima potreban je vitamin B6 za opstanak. Međutim, samo su mikroorganizmi i biljke sposobni sintetizirati ga de novo. Uloga vitamina B6 je vezana uz brojne metaboličke procese, te također ima ulogu i kao kofaktor u nekim enzimski kataliziranim reakcijama. Vitamin B6 je esencijalan za više od 100 enzima koji su uključeni u sintezu proteina. Najviše je proučavana koenzimatska aktivnost piridoksal-5'-fosfata (PLP), PLP-ovisni enzimi su uključeni u važne korake metabolizma aminokiselina, procesima dekarboksilacije i racemizacije, formiranja hemoglobina i biosintezi klorofila. Vitamin B6 bi mogao imati ulogu u sprečavanju oksidativnog stresa stanica. Manjak vitamina B6 u ljudskoj prehrani uključuje niz posljedica, odnosno nastanka bolesti, ozbiljnih i manje ozbiljnih kao npr. hiperhomocistein anemija i povećan rizik za artelosklerozu.
Keywordsvitamin B6 pyridoxine pyridoxal pyridoxamine
Parallel title (English)The chemistry of vitamin B6 and synthesis of novel analogues of vitamin B6
GranterSveučilište Josipa Jurja Strossmayera u Osijeku
Odjel za kemiju
Lower level organizational unitsZavod za analitičku, organsku i primijenjenu kemiju
PlaceOsijek
StateCroatia
Scientific field, discipline, subdisciplineNATURAL SCIENCES
Chemistry
Analytic Chemistry
Study programme typeuniversity
Study levelundergraduate
Study programmeChemistry
Academic title abbreviationuniv. bacc. chem.
Genreundergraduate thesis
Language Croatian
Defense date2016-09-20
Parallel abstract (English)
Vitamin B6 exists in three basic chemical forms: pyridoxine (an alcohol), pyridoxal (an aldehyde) and pyridoxamine (a primary amine). The three major forms can be phosphorylated at the 5'-hydroxymethyl group. The first total synthesis of vitamin B6 was obtained by the condensation of acetylacetone and cyanacetamide. All living beings need vitamin B6 for their existence. However, only microorganisms and plants are able to synthesize it de novo. The role of vitamin B6 is related to a number of metabolic processes , and also plays a role like a cofactor in certain enzyme-catalyzed reactions. Vitamin B6 is essential for more than 100 enzymes involved in protein metabolism. The most studied coenzymic activity is one of the pytidoxal-5'-phosfate (PLP), PLP-dependent enzymes are involved in important steps of amino acid metabolism, processes of decarboxylation and racemization, hemoglobin formation and chlorophyll biosynthesis. Vitamin B6 could have a role in preventing oxidative stress of the cells. A deficiency of vitamin B6 in the human diet encompasses the full spectrum of clinical disorders, some of them more serious, such as hyperhomocysteinaemia and increases the risk for atherosclerosis.
Parallel keywords (Croatian)vitamin B6 piridoksin piridoksal piridoksamin
Resource typetext
Access conditionOpen access
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:182:552557
CommitterSanda Hasenay