The need for organizations to adapt to dynamic changes in the business environment is becoming more accentuated. Technological advances, innovation and the rapid flow of information require corporations to respond quickly and constructively. Main goal of every organization is profitability which is achieved by competitive advantage. In order for an organization to take a superior position in the market, it must constantly behave entrepreneurialy, innovate and make progress. Larger corporations have an advantage when it comes to innovation, they have more employees which means that they posses a greater range of talent and a wide range of mindsets among employees. It is up to the management of each corporation to create an environment in which it can harness the talents and skills it has in the organization. Managing human resources is one of the main tasks in the corporation, and the importance is manifested in the fact that the range of skills and talents that will be employed in the organization depends on this function of management. Managing human resources means monitoring, recruiting and hiring best fitted candidates for the organizational needs. The task of this management function does not remain only on that. In addition to the above mentioned activities, human resource management also means to train, educate, guide and motivate employees. Human resources are one of the main assets in every corporation. In order for this resource to be used effectively and efficiently, it is necessary to encourage the prominent individuals who lead the organization in a successful direction with their commitment and ideas. In entrepreneurial corporations, the goal is to develop profitable products and accordingly it is necessary to develop an organizational culture that encourages success. The analysis of practical examples revealed a difference in activities between a corporation that encourages corporate entrepreneurship by empowering human resources and a corporation that bases its success on different methods of work.