This final paper discusses the concepts of globalization and regionalism, as well as their development and their impact on the economies of countries with an emphasis on European integration. There are factors of globalization such as technology development, market liberalization, and greater competitiveness presented, as well as subjects of globalization such as global institutions, but also multinational companies that have increasing economic and political influence in the world. Measurement of globalization, which is a very complex process, is explained, and the advantages and disadvantages of this process and the impact of subjects of globalization on this process are highlighted. Part of the final paper is dedicated to the threat to fundamental human rights in developing and underdeveloped countries as a result of globalization. Also, important concepts related to regionalism have been defined and the initial point of regionalism has been clarified. All terms are integrated into the European context that is closest to the Republic of Croatia due to the strong territorial, economic and political connection. The development of European integration is also explained in more detail, from further history to the first forerunner of the European Union - the European Coal and Steel Community. In addition, the regional policy of the European Union was clarified, with emphasis on the core documents that are partly responsible for the current regional division, and macro-regional strategies of the European Union, which connects territorially close countries with a common geographical link in certain EU macro-regions. The role of the process of globalization and regionalism in the development of the European Union and the Republic of Croatia is presented below.