The self-destructive behavior of the addiction to psychoactive drug substances does not only negatively affect the individual's personal health, causing changes in motor, cognitive and volitional aspects of personality, but this problem also involves the family of addicts and entails a number of social consequences, becoming a global phenomenon which takes very high place in the ranking of national security priorities. Sociologically - culturally and criminally-legally, many measures of prevention, rehabilitation and punishment are made. Medical-psychological efforts are made in treating and overcoming the abstinence crisis. But the Church Pastoral Service has also a significant role in designing motivational programs and developing the spiritual support of addicts and their families. In order to present this complex problem of self-destructive addictive behavior, this work is conceived through four fundamental units that complement each other by keeping a description of the title and subtitle, offering an integrative model of pastoral strategy to suppress addiction and to work with addicts and their near ones. The general units of this paper are next: I. ETHIOLOGY OF ABUSE OF PSYCHOATIC SUBSTANCES AND ADDICTION II. SOCIAL, FAMILY AND PERSONAL PREDISPOSITIONS FOR THE DEVELOPMENT OF ADDICTIVE BEHAVIOR III. LEGISLATION AND PREVENTIVE MEASURES IV. PASTORAL MODELS OF A SPIRITUAL APPROACH TO LIBERATION FROM ADDICTION