undergraduate thesis
Antiestrogenic effects of indoles from green leafy vegetables

Josipa Matuha (2016)
Josip Juraj Strossmayer University of Osijek
Department of biology
Metadata
TitleAntiestrogeno djelovanje indola iz zelenog lisnatog povrća
AuthorJosipa Matuha
Mentor(s)Valentina Pavić (thesis advisor)
Abstract
Zeleno lisnato povrće skupina je biljaka koja pripada porodici Brassicaceaea. Bogato je indolima, koji su produkt hidrolize glukozinolata. U potencijalno korisne aktivnosti glukozinolata i proizvoda njihove enzimatske hidrolize ubrajaju se antifungalna, antibakterijska, bioherbicidna, biopesticidna, antioksidativna, antimutagena iantikancerogena aktivnost. Indol 3-karbinol i i diindolilmetan (DIM) su ključne bioaktivne molekule zelenog lisnatog povrća. Djeluju kao antiestrogeni, odnosno antagonisti receptora estrogena, na način da blokiraju ili ometaju receptor za estrogen. Induciraju enzim koji pretvara estron u 2-OHE na trošak 16 -OHE, a povećanje omjera 2:16 -hidroksiestrona povezano je sa smanjenjem rizika od raka dojke.
Keywordsindole antiestrogen action green leafy vegetables
Parallel title (English)Antiestrogenic effects of indoles from green leafy vegetables
Committee MembersValentina Pavić (committee chairperson)
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
PlaceOsijek
StateCroatia
Scientific field, discipline, subdisciplineNATURAL SCIENCES
Biology
Study programme typeuniversity
Study levelundergraduate
Study programmeUndergraduate University Study Programme in Biology (Bachelor of Science)
Academic title abbreviationuniv.bacc.biol.
Genreundergraduate thesis
Language Croatian
Defense date2016-09-19
Parallel abstract (English)
Green leafy vegetables are a group of plant families Brassicaceaea. They are richin indoles, which are products of hydrolysis of glucosinolates. Potentially useful activities of glucosinolates and products of their enzymatic hydrolysis includes antifungal, antibacterial,bioherbicidal, biopesticidal, antioxidant, anticancer and antimutagenic activity. Indole 3-carbinol and the diindolilmetan (DIM) are a key bioactive molecules of green leafy vegetables. They act as anti estrogens or estrogen receptor antagonists, by blocking orcounteract estrogen receptor.They induce an enzyme that converts estrone in 2 -OHE to cost16 -OHE , and an increase in the ratio of 2:16 -hidroksiestron associated with reduced riskof breast cancer.
Parallel keywords (Croatian)indol antiestrogeno djelovanje zeleno lisnato povrće
Resource typetext
Access conditionOpen access
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:181:451218
CommitterVesna Radman Meic