master's thesis
Association of osteoprotegerin gene polymorphisms and osteoporosis inpostmenopausal women

Lucija Kuna (2013)
Josip Juraj Strossmayer University of Osijek
Department of biology
Metadata
TitlePovezanost polimorfizama osteoprotegerin gena i nastanka osteoporoze kod postmenopauzalnih žena
AuthorLucija Kuna
Mentor(s)Elizabeta Has Schon (thesis advisor)
Martina Smolić (thesis advisor)
Abstract
Osteoporoza je česta bolest uslijed koje dolazi do smanjenja koštane mase. Nedostatak u mikroarhitekturi koštanog tkiva negativno utječe na čvrstoću kostiju te dovodi do povećanog rizika od prijeloma kostiju. Osteoprotegerin gen (OPG) vrlo je bitan u genetičkoj kontroli koštane mase te ima vrlo značajnu ulogu u nastanku osteoporoze. Najčešći tip polimorfizma pripada SNP polimorfizmu. Otkriće receptora aktivatora nuklearnog faktora kb (RANK)/RANK ligand RANKL/OPG pridonio je boljem razumijevanju načina regulacije formacije i resorpcije kosti.RANK-RANKL-OPG sustav mogao bi biti usmjeren kao nova strategija liječenja bolesti.
Keywordsosteoporosis osteoprotegerin gene postmenopausal age bone mineral desity (BMD) RANK/RANKL/OPG system polymorphism
Parallel title (English)Association of osteoprotegerin gene polymorphisms and osteoporosis inpostmenopausal women
Committee MembersElizabeta Has Schon (committee chairperson)
Marija Heffer (committee member)
Martina Smolić (committee member)
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
PlaceOsijek
StateCroatia
Scientific field, discipline, subdisciplineNATURAL SCIENCES
Biology
Study programme typeuniversity
Study levelgraduate
Study programmeMaster of Science Graduate University Study Programme in Biology; specializations in: Master of Biology
Study specializationMaster of Biology
Academic title abbreviationmag.biol.
Genremaster's thesis
Language Croatian
Defense date2013-10-24
Parallel abstract (English)
Osteoporosis is a common disease characterized by low bone mass. Reduced microarchitecture of bone tissues affects bone strength leading to an increased risk of bone fractures .Osteoprotegerin gene (OPG) is an important candidate gene of osteoporosis and may have an important role in development of osteoporosis. SNP polymorphism is the most common type of polymorphism. Discovery of the receptor activator of nuclear factor RANK/RANK ligand RANKL/OPG contributed to understanding of bone formation and resorption. Targeting of RANK- RANKL-OPG system may represent a new strategy in the treatment of bone diseases.
Parallel keywords (Croatian)osteoporoza osteoprotegerin gen postmenopauzalna dob mineralna gustoća kostiju (BMD) RANK/RANKL/OPG sustav polimorfizam
Resource typetext
Access conditionOpen access
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:181:713849
CommitterVesna Radman Meic